Process for preparing a pharmaceutical formulation containing levothyroxine sodium

Abstract:

The invention relates to a pharmaceutical preparation comprising levothyroxine sodium, gelatin and fillers, which is free of organic solvent residues.

Citations

3621096 3808332 5225204

Cited By

Patent number	Title	Issue date
7052717	Storage stable thyroxine active drug formulations and methods for their production	2006-05-30

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Claims:

What is claimed is:

1. A process for the production of a pharmaceutical preparation, comprising spraying levothyroxine sodium and optionally liothyronine sodium, in suspended form in aqueousgelatin solution, onto a filler(s) in a fluidized bed granulation, admixing a disintegrant and lubricant and compressing the mixture to give tablets.

2. A process according to claim 1, wherein the filler is lactose, maize starch or microcrystalline cellulose.

3. The process according to claim 1, wherein The disintegrant used is croscarmellose sodium and the lubricant used is magnesium stearate.

Patent number:
6646007
View patent at USPTO

Filing date:
November 15, 2000

Issue date:
November 11, 2003

Inventors:
Marion Nischwitz (Darmstadt, DE)
Sven Schreder (Heidelberg, DE)

Assignee:
Merck Patent GmbH (Darmstadt, DE)

Primary Examiner:
Phyllis G. Spivack

Attorney, Agent or Firm:
Millen, White, Zelano & Branigan, P.C.

Current U.S. Classification: 514/567